L. Peeters, S. Jacobs, W. Eevers
1994
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron
Abstract
Abstract 3-Methoxy-2,5-dimethylthiophene and 3,4-dimethoxy-2,5-dimethylthiophene have been prepared from 3,4-dibromo-2,5-dimethylthiophene and sodium methoxide using Cu(I)Br as a catalyst. The influence of some cosolvents and reaction temperature is investigated. Best results are obtained by refluxing in DMF at 125°C for 4 hours. The mixture is easily separated by flash chromatography.