Subhajit Mishra, A. Hajra
Oct 7, 2015
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A new strategy has been developed for the synthesis of 4-oxo-pyrido[1,2- a ]pyrimidine-3-carbonitriles through Cu(I)-catalyzed annulation between 2-aminopyridine and arylidenemalononitriles under oxygen atmosphere. The transformation occurs through mechanistically different steps of aza-Michael addition, aerobic dehydrogenation, and intramolecular amidination followed by hydrolysis under Cu-catalysis.