Dengke Li, Tingting Mao, Jinbo Huang
Jun 22, 2018
Citations
1
Influential Citations
33
Citations
Journal
The Journal of organic chemistry
Abstract
A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent, has been disclosed. The reaction proceeds under mild conditions, and possible byproducts generated from hydrodifluoroacetylation and/or direct alkenyl C-H difluoroacetylation are not observed. Mechanistic studies confirm that the atom transfer radical addition (ATRA) process is involved in this alkene difunctionalization reaction.