Shaoqun Zhu, Haibo Yang, A. Jiang
Nov 11, 2020
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Influential Citations
13
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Journal
The Journal of organic chemistry
Abstract
A copper-catalyzed bromodifluoroacetylative cyclization reaction is described. The treatment of bromodifluoroacete derivatives by CuI and B2Pin2 enables difluoroalkyl radical generation and triggers the radical addition/cyclization/bromination sequences. Bromodifluoroacetyl-derived ester, amide, and ketone were compatible and gave various vinyl C-Br bonds containing functionalized heterocycles in good yields.