Q. Yuan, Weidong Rao, Shun‐Yi Wang
Dec 11, 2019
Citations
0
Influential Citations
8
Citations
Journal
The Journal of organic chemistry
Abstract
A copper-catalyzed intramolecular cyclization reaction of 2-isocyanoacetophenone derivatives to afford 4-hydroxyquinolines chemoselectively is described. The transformation proceeds through enol tautomerism and subsequently C-C bond formation. Compared to previous methods, this study provides a new protocol for the construction of 4-hydroxyquinoline compounds from functionalized isocyanides under mild conditions.