Fei Wang, Peng Zhao, C. Xi
Jan 12, 2011
Citations
0
Influential Citations
29
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Copper-catalyzed tandem reaction of ortho -bromobenzamides and isothiocyanates is described, which provides an efficient and practical route for the synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1 H )-ones. The optimal condition involved the following parameters: CuI as precatalyst, Cs 2 CO 3 as base, N , N ′-dimethylethane-1,2-diamine as ligand, and toluene as solvent, with reaction temperature at 120 °C.