S. Crotti, F. Berti, M. Pineschi
Sep 6, 2011
Citations
0
Influential Citations
23
Citations
Journal
Organic letters
Abstract
A regioselective introduction of a methoxycarbonyl methyl group at the C(2) position of unsubstituted pyridine has been accomplished with catalytic amounts of copper(II) triflate in mild reaction conditions. The N-acetyl-1,2-dihydropyridyl acetic acid methyl ester obtained is a valuable building block for the synthesis of new polyfunctionalized piperidine derivatives bearing unconventional substitution patterns.