Xiao‐Feng Xia, Su-Li Zhu, Jian-Biao Liu
Dec 5, 2016
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0
Influential Citations
23
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Journal
The Journal of organic chemistry
Abstract
A facile copper-catalyzed radical aminoarylation of acrylamide with N-fluorobenzenesulfonimide (NFSI) is described. In the presence of copper acetate and 1,10-phenanthroline, a range of isoquinoline-1,3-diones can be constructed in moderate to good yields using NFSI as the amination reagent. Mechanistic studies demonstrated the reaction went through a sequential radical addition and cyclization pathway, which was supported by DFT calculations.