S. Shi, Lei-lei Sun, Zhiyong Liao
Mar 1, 2012
Citations
0
Influential Citations
12
Citations
Journal
Synthesis
Abstract
A copper-catalyzed regio- and stereoselective 6- exo -dig cyclization of 1-chloro-1,5-enynes with sodium hydrosulfide has been developed. In the presence of copper(I) iodide and sodium tert -butoxide, a variety of ( Z )-1-methylene-3-(trifluoromethyl)-1 H -isothiochromenes were prepared in moderate to good yields via thiolation cyclization of 1-alkynyl-2-(2-chloro-3,3,3-trifluoroprop-1-enyl)benzenes with sodium hydrosulfide.