R. Motoki, M. Kanai, M. Shibasaki
Jul 13, 2007
Citations
1
Influential Citations
106
Citations
Quality indicators
Journal
Organic letters
Abstract
A general method for direct alkynylation of trifluoromethyl ketones was developed by using CuO(t)Bu-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst preparation step, exhibited some acceleration effects. A preliminary extension to a catalytic enantioselective CF3-substituted tertiary propargyl alcohol synthesis (up to 52% ee) is also described.