Congjun Xu, Mingze Qin, Jun Yi
May 5, 2017
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Journal
RSC Advances
Abstract
A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was implemented via an oxygen mediated radical mechanism. Potassium ferricyanide played a dual role as a “CN” source and also as a coupling partner for the cyclization of oxazole.