Jinho Kim, Hyunwoo Kim, Sukbok Chang
Jul 13, 2012
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Influential Citations
105
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Quality indicators
Journal
Organic letters
Abstract
Copper-mediated regioselective cyanation of indoles and 2-phenylpyridines was developed by using ammonium iodide and DMF as the combined source of a cyano unit under "Pd-free" conditions. Mechanistic studies indicate that the reaction of indoles proceeds through a two-step sequence: electrophilic initial iodination and then cyanation. The cyanation has a broad substrate scope, high functional group tolerance, and excellent regioselectivity.