A. Rinaldi, G. Ponticelli, S. Oliva
May 1, 2000
Citations
0
Influential Citations
4
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Topaquinone (TPQ) is a cofactor present at the active site of copper amine oxidases, derived from a Tyr residue inserted in the polypeptide chain through a copper-dependent but otherwise largely unknown mechanism. A simple model system was developed that permits to obtain the overall transformation of 4-tert-butylphenol, chosen as a model for Tyr, into a TPQ-like, para-hydroxyquinonic structure in the presence of Cu(II)-imidazole mononuclear complexes.