R. I. Glazer, A. L. Peale
Mar 30, 1978
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract Cordycepin and xylosyladenine inhibited methylation of nuclear RNA to a greater extent than RNA synthesis in L1210 cells in vitro . Inhibition of base methylation, 2′-0-methylation and 5′cap methylation was equal to, 2 to 5-fold greater and 1.5-fold greater, respectively than inhibition of RNA synthesis. Cordycepin was more potent than xylosyladenine in inhibiting 2′-0-methylation of cytidine and adenosine, but not guanosine. These results suggest that impirment in the 2′-0-methylation of nuclear RNA may be one of the major effects that limits the biological activity of rRNA and mRNA by these drugs.