K. Hemminki, K. Falck
Aug 1, 1979
Citations
0
Influential Citations
77
Citations
Quality indicators
Journal
Toxicology Letters
Abstract
Abstract The reactivity of simple epoxides with 4-( p -nitrobenzyl)-pyridine was compared with their mutagenicity in Salmonella typhimurium TA 100 and Escherichia coli WP 2 uvrA. The order of reactivity correlated well with mutagenicity, trichloropropylene oxide being most potent followed by epichlorohydrin, styrene oxide, glycidol and propylene oxide. The results suggest that 4-( p -nitrobenzyl)-pyridine alkylation is a simple and reliable primary assay in the evaluation of mutagenic properties.