Jui-Ying Cho, T. Hwang, Tsung-Hsien Chang
Nov 1, 2012
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Influential Citations
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Quality indicators
Journal
Food Chemistry
Abstract
Abstract Zanthoxylum avicennae is commercially used as healthcare products for the improvement of chronic hepatitis and rheumatism. Its fruit is also used as a spice. Five new coumarins, 5′-methoxyauraptene ( 1 ), 6,5′-dimethoxyauraptene ( 2 ), 5′-methoxycollinin ( 3 ), 7-((2′ E ,5′ E )-7′-methoxy-3′,7′-dimethylocta-2′,5′-dienyloxy)coumarin ( 4 ), and 6-methoxy-7-((2′ E ,5′ E )-7′-methoxy-3′,7′-dimethylocta-2′,5′-dienyloxy)coumarin ( 5 ), have been isolated from the leaves of Z. avicennae , together with 15 known compounds ( 6 – 20 ). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 6 , 9 – 15 , and 18 exhibited inhibition (IC 50 ⩽ 8.29 μg/ml) of superoxide anion generation by human neutrophils in response to formyl- l -methionyl- l -leucyl- l -phenylalanine/cytochalasin B (fMLP/CB). Compounds 6 , 10 , 12 , 14 , and 18 inhibited fMLP/CB-induced elastase release with IC 50 values ⩽6.30 μg/ml.