Robert Bierstedt, Friedrich A. von Hayek
1952
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Abstract
A two-step process for the preparation of 6,6-alkylenedioxyheptan-2-one starting from diketene and formaldehyde is described. In the first step, diketene and formaldehyde are reacted to form 2,6-heptanedione. Selective ketalization of the latter compound results in the formation of 6,6-alkylenedioxyheptan-2-one as major product. Recycle of by-product diketal obtained in this step is also described. The final product is useful as an intermediate in the total synthesis of medicinally valuable steroids.