C. Pan, Chaoyue Chen, Jin‐Tao Yu
Feb 1, 2017
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Influential Citations
17
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Journal
Organic & biomolecular chemistry
Abstract
Alkyl-substituted isoquinoline-1,3(2H,4H)-diones were prepared by decarbonylative coupling of N-alkyl-N-methacryloylbenzamides and aliphatic aldehydes under metal-free conditions. The reaction undergoes subsequent decarbonylation, radical addition and cyclization processes with aliphatic aldehydes as the cheap and abundant alkyl radical source. This procedure offers a complementary approach to the convenient generation of alkyl-substituted isoquinoline-1,3(2H,4H)-diones.