Pengli Bao, Leilei Wang, Qishun Liu
Jan 17, 2019
Citations
0
Influential Citations
40
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple and efficient method has been developed for construction of sulfonylated quinolines via coupling of haloquinolines and sulfonyl chlorides in water. The present methodology provides an attractive approach to various sulfonylated quinolines in moderate to good yields with favorable functional group tolerance, which has the advantages of operation simplicity, readily available starting materials, excellent regioselectivity, scale-up synthesis, and organic solvent-free conditions.