Baolong Huo, Manman Du, A. Shen
Aug 15, 2019
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Influential Citations
34
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Journal
Analytical chemistry
Abstract
The highly selective and sensitive fluorescence "light-up" probe, 5'-(dimethylamino)-2'-formyl-N-hydroxy-[1,1'-biphenyl]-2-carboxamide (PTS), has been fabricated for the nerve agent mimic diethyl chlorophosphate (DCP). The probe is designed by combining two novel strategies of "covalent assembly" and Lossen rearrangement. The formation of a phosphoryl inter-mediate from DCP and a hydroxamic acid group in PTS yields an isocyanate that quickly undergoes the Lossen rearrangement to produce an aniline that condenses intramolecularly to a fluorescent phenanthridine system. PTS shows superior properties to probe DCP, such as rapid response (within 100 s), low detection limit (10.4 nM), specificity and excellent linearity (R2=0.9993) in range of 2 μM to 16 μM. More importantly, its application of detecting DCP vapor has also been achieved with satisfying results.