E. Kleinman, A. Fray, W. Holt
Feb 24, 1994
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract CP-71,362 (Boc-Phe-His-hexahydroPhe[OH]Leu-Lys-Phe) has been identified as the most potent inhibitor of rat plasma renin (IC50 = 3 nM) and dog plasma renin (IC50 = 3 pM) to date and thus can be used as an important experimental tool in the study of the renin angiotensin system in these established hypertensive models.