D. Haydon, J. Bennett, David R. Brown
Apr 28, 2010
Citations
2
Influential Citations
87
Citations
Quality indicators
Journal
Journal of Medicinal Chemistry
Abstract
3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure−activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.