G. Stavber, Zdenko Časar
Aug 1, 2014
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Influential Citations
33
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Journal
ChemCatChem
Abstract
Organoboron compounds 2] actuate an on-going interest in chemistry owing to their versatile applicability. Indeed, in recent years biological significance of these compounds has been clearly established. A breakthrough advance in this area was achieved when bortezomib 5] was approved as the first proteasome inhibitor for human use in the frontline treatment of multiple myeloma. This encouraged further development in the area and many new compounds of this type are currently being investigated, among which ixazomibe and delanzomibe are in advanced clinical stages. Moreover, dutogliptin, a dipeptidyl peptidase 4 (DPP4) inhibitor that contains an a-aminoboronic acid moiety, has been investigated for treatment of type 2 diabetes mellitus (Figure 1). In addition, nowadays organoboranes find important applications in chemistry of materials and as essential reagents in important chemical transformations. The unique reactivity of C B bond makes this class of compounds distinct in many ways. Namely, the creation of C B bonds in organic frameworks offers many interesting possibilities for the subsequent functional group transformations and application in the synthesis of complex molecules. The most prominent examples of these transformations are oxidations, cross-couplings, allylborations, 16] homologation sequences, 1,2-migrations, 19] amine synthesis, Petasis reaction, carbonylations, and many others others 23] (Scheme 1).