Hesheng Zhang, Dan Xu, Jie Zhang
Oct 22, 2019
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Journal
Journal of Inorganic and Organometallic Polymers and Materials
Abstract
A new type of glycine bridged Cu(II)-containing Schiff base coordination polymer {[Cu 2 (HL) 2 ](H 2 O) 4 } n ( 1 , H 3 L = (2,2′-(((1E,1′E)-(2-hydroxy-5-methyl-1,3-phenylene)bis(methaneylylidene))bis(azaneylylidene))diacetic acid) was composed by the condensation of glycine, Cu(NO 3 ) 2 ·6H 2 O as well as 2,6-diformyl-4-methylphenol in the water surrounding. To make the size of complex 1 in nanoscale, a green grinding treatment approach was utilized to generate the nano sheets of complex 1 which has excellent water dispersibility. We firstly constructed the primary focal segmental glomerulosclerosis mice model and evaluate the reduction effect of nano 1 on the level of 24-h urine protein contents. Then, the nf - κb and tlr4 gene expression level was measured by RT-PCR to reveal the mechanism of nano 1 . Further, motivated by the drug-like potential that observed from experimental results, the binding interaction has been probed by using molecular docking simulation.