Hiroyuki Kawai, T. Furukawa, Y. Nomura
Jun 13, 2011
Citations
0
Influential Citations
101
Citations
Quality indicators
Journal
Organic letters
Abstract
Copper-mediated chemoselective trifluoromethylation at the benzylic position by the use of shelf-stable electrophilic trifluoromethylating reagents 3 in good to high yields under mild conditions is described for the first time. The generality of this trifluoromethylation for a wide variety of benzyl bromides facilitates the rapid creation of structural diversity of medicinal candidates in drug discovery.