R. Hulme, O. Zamora, E. J. Mota
Apr 7, 2008
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron
Abstract
Abstract 4-Aryl-2-cyanoimino-3,4-dihydro-1 H -pyrimidine derivatives were prepared using a multicomponent reaction by reacting a mixture of arene or heteroarenecarbaldehyde, 1,3-dicarbonyl compounds, and cyanamide under acidic conditions. The novelty of this approach derives from its use of cyanamide as a building block in a four-component Biginelli-type reaction. Varying the reaction conditions led to the formation of either N -(2-imino-6-phenyl-1,3,5-oxadiazinan-4-ylidene) cyanamide or 3,4-dihydropyrimidin-2(1 H )-one. The type of heterocycle skeleton synthesized depends on the nature of the acid catalyst as well as the reaction conditions employed.