Yue Zhang, Tingting Liu, Yifeng Yu
Jun 1, 2014
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Journal
Advanced Materials Research
Abstract
A scalable and cycle process for 2,4-dibromopyrimidine is developed by bromination of 2,4-dichloropyrimidine using phosphorus tribromide. Compared with the literature reported before, the amount of bromination agent-phosphorus tribromide has been greatly reduced and purification of the product by recrystallization is realized. The total yield of 2,4-dibromopyrimidine can reach to 85.4%. The process is more suitable for scale-up production.