A. Somlyo, A. Somlyo, N. Friedmann
Dec 1, 1971
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Influential Citations
37
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Journal
Annals of the New York Academy of Sciences
Abstract
Cyclic adenosine 3’,5’-monophosphate (cyclic AMP) is considered to be the secondary messenger of 8-adrenergic actions on the membrane potential of vascular smooth muscle and cerebellar Purkinje 3 The purpose of our study was to determine whether cyclic AMP also has an effect on the membrane potential of the liver, an organ in which it is known to be a major metabolic regu1ator.l We further wanted to correlate the membrane potential change that may be produced by cyclic AMP with its effect on hepatic ion fluxes and to establish whether agents whose metabolic actions are mediated by cyclic AMP, such as glucagon and isoproterenol, also produce effects on the liver cell membrane similar to those of cyclic AMP. Finally we wanted to determine whether cyclic guanosine 3’,5’-monophosphate (cyclic GMP) has an effect similar to that of cyclic AMP on the liver cell membrane potential and K+ efflux, since cyclic GMP is a naturally occurring cyclic nucleotide with effects on liver metabolism similar to those of cyclic A brief account of these findings has been published.x