H. Shue, Xiao Chen, J. Schwerdt
Feb 15, 2006
Citations
0
Influential Citations
18
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an alpha-methyl group at the benzylic position to improve potency and duration of in vivo activity are discussed. Several compounds with high affinity and sustained in vivo activity were identified.