J. Bryans, N. Chessum, Nathalie Huther
Aug 11, 2003
Citations
0
Influential Citations
40
Citations
Journal
Tetrahedron
Abstract
The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam.