M. Otmar, M. Masojídková, A. Holý
Jan 6, 1997
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract Reductive cylization of 6-(1-cyanoalkyl)-5-nitropyrimidines leads to 7-alkyl-5 H -pyrrolo[3,2- d ]pyrimidines. The presence of two alkyl substituents at the cyanomethyl group results in formation of 6-amino-7,7-dialkyl-7 H -pyrrolo-[3,2- d ]pyrimidines. By this method 7-(2,3-dihydroxypropyl)-2,4-dimethoxy-5 H -pyrrolo[3,2- d ]pyrimidine was prepared as an intermediate for the preparation of 9-deaza analogues of DHPA and related compounds.