M. Ponpipom, R. Bugianesi, J. C. Chabala
1988
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Acid catalyzed cyclization of (1 R ,4 RS )- and (1 S ,4 RS )-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis - and trans -tetrahydrofurans proceeds with retention of configuration at C-1. Using this stereo- and regioselective reaction, the two optically active enantiomers of L-659,989, a potent PAF-receptor antagonist, were prepared.