Dao‐Cai Wang, Yongmei Xie, Chen Fan
Jul 1, 2014
Citations
0
Influential Citations
28
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel 2-amino-4 H -pyran derivatives have been synthesized via a three-component reaction of α , β -unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer (HCT116), human cervical cancer (Hela), and non-small cell lung cancer (H1975).