Kaifan Zhang, Chi Yang, Hequan Yao
Aug 29, 2016
Citations
0
Influential Citations
51
Citations
Journal
Organic letters
Abstract
A novel [3 + 2] cycloaddition reaction between in situ formed azaoxyallyl cations and aldehydes has been developed. This concise method allows the rapid formation of a number of oxazolidin-4-ones in high yields with good functional group tolerance at room temperature. Further transformation and late-stage modifications of drug molecules could also be achieved in good yields, highlighting the potential utility of the reaction.