Toshimichi Ohmura, Akihito Kijima, Yusuke Komori
Jul 5, 2013
Citations
0
Influential Citations
20
Citations
Journal
Organic letters
Abstract
Reaction of N-alkylisoindoles with (bromoethynyl)triisopropylsilane afforded 1,3-bis(triisopropylsilylethynyl) isoindoles in high yields. The formal C-H alkynylation proceeds under transition-metal-free conditions through [4 + 2] cycloaddition of the pyrrole ring of isoindole with bromoalkyne followed by ring-opening of the product.