N. Katagiri, Masayuki Sato, N. Yoneda
1986
Citations
0
Influential Citations
16
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
2-Azabicyclo[2.2.0]hexane-3,5-dione has been synthesized via photopyridone formation from 4-(dimethyl-t-butylsiloxy)- or 4-alkoxy-2-pyridones followed by mild acid hydrolysis. The title compound and its derivatives react with a variety of nucleophiles (ROH, RR′NH, RSH, or RMgBr) to give azetidin-2-ones having an acetic acid or acylmethyl side-chain at the 4-position, and hence serve as new building blocks for carbapenem nuclei.