R. I. Gelb, L. M. Schwartz, D. A. Laufer
Jul 4, 1983
Citations
0
Influential Citations
6
Citations
Journal
Life sciences
Abstract
Spectrophotometric and pH potentiometric studies indicate that cyclohexaamylose (alpha-cyclodextrin) and cycloheptaamylose (beta-cyclodextrin) form aqueous complexes with all adamantane derivatives examined to date. Thermodynamic complex formation constants are reported for the substrates 1-adamantaneamine (amantadine), 1-adamantaneammonium ion, 1-adamantanemethylamine, 1-adamantane-methylammonium ion, 1-adamantanecarboxylic acid, 1-adamantane-carboxylate ion, 1-adamantaneacetic acid and 1-adamantaneacetate ion. The existence of these complexes implies that cycloamylose might serve as a therapeutic sequestering agent for adamantane derivatives.