H. Bonacorso, Itamar S. Lopes, A. D. Wastowski
Mar 1, 2003
Citations
0
Influential Citations
32
Citations
Journal
Journal of Fluorine Chemistry
Abstract
The synthesis of a novel series of eleven 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones, where aryl ¼ Ph, 4-CH3Ph, 4-FPh, 4ClPh, 4-BrPh, 4-OCH3Ph and alkyl ¼ H, CH3, from the reaction of 4-aryl-4-methoxy-1,1,1-trifluoro-3-buten-2-ones with urea in the presence of hydrochloric acid, is reported. Trifluoroacetylation of acetophenone- and propiophenone-dimethylacetals derived from phenones, was employed to obtain the precursors. # 2002 Elsevier Science B.V. All rights reserved.