E. Edstrom, Tao Yu
Sep 19, 1994
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
Abstract This paper describes an efficient new route for the synthesis of pyrrolo[3,2- c ]pyridin-2-ones and pyrido[3,4- b ]pyrrolizidin-1-ones starting from 4-chloro- N -benzyl-2(1 H )-pyridinone and amino acid salts. Intermediate 4-[(carboxymethyl)amino]pyridin-2-ones undergo an acylative cyclodehydration reaction to afford 3-acetoxy pyrroles. These intermediates are then converted into 3-oxytriflate derivatives in high yield using a new one-step method. These compounds undergo palladium catalyzed methoxycarbonylation.