S. Fanali, Z. Aturki
Mar 3, 1995
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0
Influential Citations
109
Citations
Quality indicators
Journal
Journal of Chromatography A
Abstract
Abstract The enantiomeric separation of racemic compounds of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs (profens), namely fenoprofen, ibuprofen, flurbiprofen, suprofen, ketoprofen and indoprofen, was performed by capillary zone electrophoresis. The separation was obtained by supporting the background electrolyte with derivatized β-cyclodextrins. The type and concentration of cyclodextrin used and the background electrolyte composition (pH and amount of methanol) influenced the complexation and the chiral resolution. All the modified β-cyclodextrins used (heptakis-2,6-di-O-methyl-β-, heptakis-2,3,6-tri-O-methyl- and 6 A -methylamino-β-cyclodextrin) showed good complexing effects with the profens tested. Tri-O-methyl-β-cyclodextrin proved to be the best stereoselective additive because it allowed the enantiomeric resolution of all the profens studied whereas the dimethylated and methylamino-β-cyclodextrin were able to separate only some of them.