Satish D. Mitragotri, Poonam H Khyadage, Diksha S Chorghade
Dec 16, 2023
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Journal
Arkivoc
Abstract
Cyclohexylamine was found to be an efficient organocatalyst for the synthesis of structurally diverse 2-amino-4 H -chromenes by multicomponent reaction of (substituted) salicylaldehydes, active methylene compounds and nitroalkanes at ambient temperature and under solvent-free conditions. The synthesis of a variety of 2-amino-4 H -chromenes was achieved using the reaction of (substituted) salicylaldehydes with two different C-H acids. The present protocol, which employed commercially available cyclohexylamine as an organocatalyst