Elina M. Jarho, J. Venäläinen, J. Huuskonen
Oct 1, 2004
Citations
0
Influential Citations
65
Citations
Journal
Journal of medicinal chemistry
Abstract
With the aim to replace the natural amino acid proline by a proline mimetic structure, a cyclopent-2-enecarbonyl moiety was studied at the P2 position of prolyl oligopeptidase (POP) inhibitors. The cyclopent-2-enecarbonyl moiety proved to be an excellent proline mimetic at the P2 position of POP inhibitors. The replacement is particularly useful when increased lipophilicity is needed.