Silje Melnes, Annette Bayer, O. R. Gautun
Oct 7, 2012
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract A study on transition metal catalyzed alkyne cyclotrimerization of unsymmetrically bromo-substituted diynes with ethynyltrimethylsilane was carried out to prepare bicyclic bromobenzene key intermediates for the total synthesis of five potential tyrosine kinase 2 inhibitors. Two different pre-catalysts (Cp*RuCl(cod) and [Rh(cod)2]BF4/BINAP) and different reaction conditions have been examined.