S. Aksoy, A. Uzel, E. Bedir
Jul 1, 2015
Citations
0
Influential Citations
22
Citations
Journal
The Journal of Antibiotics
Abstract
Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional (1H and 13C) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3’s formation from amicetin.