E. Schmidt, B. Ryabchenko, Juergen Wanner
Jan 1, 2015
Citations
2
Influential Citations
9
Citations
Quality indicators
Journal
Natural Product Communications
Abstract
The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC50: 26.1±1.9 μM) showed the strongest cytotoxic properties similar to those of curcumin (CC50: 8.1±1.7 μM). Further studies also revealed that the cytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein