P. Thuong, Tran Manh Hung, N. Khoi
Mar 1, 2014
Citations
1
Influential Citations
35
Citations
Quality indicators
Journal
Archives of Pharmacal Research
Abstract
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.