P. Edwards, D. L. Foster, L. N. Owen
1973
Citations
0
Influential Citations
6
Citations
Journal
Journal of the Chemical Society. Perkin transactions 1
Abstract
New or improved syntheses are reported of the nitrogen mustards named in the title, and of methyl m-(bis-2-chloroethylamino)-p-hydroxybenzoate. By reactions of the amines with aryl chloroformates, or of the phenols with aryl isocyanates or with isocyanates derived from α-amino-esters, carbamates containing alkyl, chloro-, alkoxy-, hydroxy-, methoxycarbonyl, carboxy-, acetyl, and sulphamoyl groups are obtained. Some of these have shown marked anti-tumour activity. p-(Bis-2-chloroethylamino)phenyl chloroformate has been prepared; it provides an alternative route to mustard carbamates. Some carbamates of the lachrymator type have been synthesised from p-aminophenacyl chloride.