V. Moinet-Hedin, T. Tabka, F. Sichel
1997
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Summary Thirty-seven new 5,11-dimethyl-6 H -pyrido[3,2- b ]carbazole derivatives have been synthesized. These compounds are structurally related to the 5,11-dimethyl-6 H -pyrido[4,3- b ]carbazole antitumor drug ellipticine. They bear either a fluorine, a bromine or a chlorine atom on position 9, and are variously substituted on the pyridine ring. Twenty-nine of these compounds (78%) were found active when tested in vitro for their cytotoxic activity in a clonogenic assay using murine leukemia L1210 cell line. Structure-activity relationships are described in detail.