N. Modi, M. Dresser, D. Desai
Mar 1, 2007
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
The Journal of Clinical Pharmacology
Abstract
Dapoxetine is being investigated for the treatment of premature ejaculation. This study evaluated the potential pharmacokinetic and cognitive interactions of dapoxetine 60 mg with ethanol 0.5 g/kg in a single‐center, double‐blind, randomized, placebo‐controlled crossover study in healthy adult male participants (n = 24). Dapoxetine was rapidly absorbed and eliminated; peak concentrations were noted 1.47 hours after administration and decreased with an alpha half‐life of 1.33 hours and a terminal half‐life of 15.6 hours. Pharmacokinetic parameters (Cmax, AUC∞, t1/2, and tmax) of dapoxetine were not altered with concurrent ethanol consumption. Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol.