Ling Li, Qian Chen, Hong Xu
Jul 5, 2020
Citations
0
Influential Citations
5
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient synthesis of bisisothiazole-4-yl disulfides via the demethoxylative thioannulation of alkynyl oxime ethers with odorless elemental sulfur has been firstly developed. This transformation involves N-O bond cleavage, the formation of multiple C-S and N-S bonds, providing an efficient way for constructions of both isothiazoles and disulfides. Straightforward elaboration of the products to isothiazole thioethers expands the synthetic utility of this reaction.